范祖森
学术任职：国科大微免教研室副主任
研究领域：天然免疫抗感染应答调控、肿瘤干细胞调控和肿瘤免疫治疗研究
获奖及荣誉
2020年国家重点研发专项首席科学家
2019年基金委创新群体首席科学家
2018年获得北京市科技进步一等奖
2016、2018年评为中科院优秀研究生导师
2014年获得谈家桢生命科学创新奖
2010年享受国务院特殊津贴专家
2006年入选新世纪百千万人才工程国家级人才
2005年获国自然杰出青年基金资助
代表性学术成果
代表论著：
2021
1. Gu Y, Wang Y, He L, Zhang J, Zhu X, Liu N, Wang J, Lu T, He L, Tian Y*, Fan Z*. Circular RNA circIPO11 drives self-renewal of liver cancer initiating cells via Hedgehog signalling. Mol Cancer. 2021 Oct 14;20(1):132.
2. Wang Y, Wang J, Li X, Xiong X, Wang J, Zhou Z, Zhu X, Dominissini D, Gu Y, He L, Tian Y*, Yi C*, Fan Z*. N 1-methyladenosine methylation in tRNA drives liver tumourigenesis by regulating cholesterol metabolism. Nat Commun. 2021;12(1):6314.
3. Chen Z, Lu T, Huang L, Wang Z, Yan Z, Guan Y, Hu W, Fan Z*, Zhu P*. circular RNA cia-MAF drives self-renewal and metastasis of liver tumor-initiating cells via transcription factor MAFF. J Clin Invest. 2021;148020.
4. Liu B, Liu N, Zhu X, Yang L, Ye B, Li H, Zhu P, Lu T, Tian Y*, Fan Z*. Circular RNA circZbtb20 maintains ILC3 homeostasis and function via Alkbh5-dependent m6A demethylation of Nr4a1 mRNA. Cell Mol Immunol. 2021;18(6):1412-1424.
5. Chen Z, Wu J, Liu B, Zhang G, Wang Z, Zhang L, Wang K, Fan Z*, Zhu P*. Identification of cis-HOX-HOXC10 axis as a therapeutic target for colorectal tumor-initiating cells without APC mutations. Cell Rep. 2021;36(4):109431.
2020
5. Wang S, Qu Y, Xia P, Chen Y, Zhu X, Zhang J, Wang G, Tian Y, Ying J, Fan Z*. Transdifferentiation of tumor infiltrating innate lymphoid cells during progression of colorectal cancer. Cell Res. 2020 Jul;30(7):610-622.
7. Xiong Z, Xia P, Zhu X, Geng J, Wang S, Ye B, Qin X, Qu Y, He L, Fan D, Du Y, Tian Y, Fan Z*. Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis. J Exp Med. 2020 Feb 3;217(2):e20190974
8. Liu B, Ye B, Zhu X, Yang L, Li H, Liu N, Zhu P, Lu T, He L, Tian Y, Fan Z*. An inducible circular RNA circKcnt2 inhibits ILC3 activation to facilitate colitis resolution. Nat Commun. 2020 Aug 14;11(1):4076.
9. Ye B, Yang L, Qian G, Liu B, Zhu X, Zhu P, Ma J, Xie W, Li H, Lu T, Wang Y, Wang S, Du Y, Wang Z, Jiang J, Li J, Fan D, Meng S, Wu J, Tian Y, Fan Z*. The chromatin remodeler SRCAP promotes self-renewal of intestinal stem cells. EMBO J. 2020 Jul 1;39(13):e103786. Epub 2020 May 25.
2019
10. Zhu P, Zhu X, Wu J, He L, Lu T, Wang Y, Liu B, Ye B, Sun L, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y*, Fan Z*. IL-13 secreted by ILC2s promotes the self-renewal of intestinal stem cells through circular RNA circPan3. Nat Immunol. 2019;20(2):183-194.
11. Wu J, Zhu P, Lu T, Du Y, Wang Y, He L, Ye B, Liu B, Yang L, Wang J, Gu Y, Lan J, Hao Y, He L, Fan Z*. The long noncoding RNA LncHDAC2 drives the self-renewal of liver cancer stem cells via activation of Hedgehog Signaling. J Hepatol. 2019;70(5):918-929.
12. Liu B, Yang L, Zhu X, Li H, Zhu P, Wu J, Lu T, He L, Liu N, Meng S, Zhou L, Ye B*, Tian Y*, Fan Z*. Yeats4 drives ILC lineage commitment via activation of Lmo4 transcription. J Exp Med. 2019; pii: jem.20182363.
13. Zhen Xiong1,2,4, Pengyan Xia1,4, Xiaoxiao Zhu3,4, Jingjing Geng1,2, Shuo Wang1, Buqing Ye1, Xiwen Qin1,2, Yuan Qu1,2, Luyun He1,2, Dongdong Fan3, Ying Du1, Yong Tian2,3*, Zusen Fan1,2*. Glutamylation of deubiquitinase BAP1 controls self-renewal of hematopoietic stem cells and hematopoiesis. J Exp Med. 2019 (in press).
14. Wang Y, Zhu P, Luo J, Wang J, Liu Z, Wu W, Du Y, Ye B, Wang D, He L, Ren W, Wang J, Sun X, Chen R, Tian Y*, Fan Z*. LncRNA HAND2-AS1 promotes liver cancer stem cell self-renewal via BMP signaling. EMBO J. 2019 Sep 2;38(17):e101110.
2018
15. Xia P, Wang S, Xiong Z, Zhu X, Ye B, Du Y, Meng S, Qu Y, Liu J, Gao G, Tian Y*, Fan Z*. The ER membrane adaptor ERAdP senses the bacterial second messenger c-di-AMP and initiates anti-bacterial immunity. Nat Immunol. 2018;19(2):141-150.
16. Xia P, Wang S, Ye B, Du Y, Li C, Xiong Z, Qu Y, Fan Z*. A Circular RNA Protects Dormant Hematopoietic Stem Cells from DNA Sensor cGAS-Mediated Exhaustion. Immunity 2018; 48(4):688-701.
17. Zhu P, Wu J, Wang Y, Zhu X, Lu T, Liu B, He L, Ye B, Wang S, Meng S, Fan D, Wang J, Yang L, Qin X, Du Y, Li C, He L, Ren W, Wu X, Tian Y*, Fan Z*. LncGata6 maintains stemness of intestinal stem cells and promotes intestinal tumorigenesis.Nat Cell Biol. 2018; 20(10):1134-1144.
18. Wang Y, Zhu P, Wang J, Zhu X, Luo J, Meng S, Wu J, Ye B, He L, Du Y, He L, Chen R*, TTian Y*, Fan Z*. Long noncoding RNA lncHand2 promotes liver repopulation via c-Met signaling.J Hepatol 2018; 69(4):861-872.
19. Ye B, Liu B, Hao L, Zhu X, Yang L, Wang S, Xia P, Du Y, Meng S, Huang G, Qin X, Wang Y, Yan X, Li C, Hao J, Zhu P, He L, Tian Y*, Fan Z*. Klf4 glutamylation is required for cell reprogramming and early embryonic development in mice.Nat Commun. 2018; 9(1):1261.
20. Ye B, Liu B, Yang L, Zhu X, Zhang D, Wu W, Zhu P, Wang Y, Wang S, Xia P, Du Y, Meng S, Huang G, Wu J, Chen R*, Tian Y*, Fan Z*. LncKdm2b controlsself-renewal of embryonic stem cells viaactivation of transcription factor Zbtb3. EMBO J. 2018; 37(8).
2017
21. Wang S*, Xia P, Chen Y, Qu Y, Xiong Z, Ye B, Du Y, Tian Y, Yin Z, Xu Z, Fan Z*. Regulatory Innate Lymphoid Cells Control Innate Intestinal Inflammation. Cell. 2017;171(1):201-216.
22. Liu B, Ye B, Yang L, Zhu X, Huang G, Zhu P, Du Y, Wu J, Qin X, Chen R*, Tian Y*, Fan Z*. Long non-coding RNA lncKdm2b is required for the maintenance of group 3 innate lymphoid cells by initiating Zfp292 expression. Nat Immunol. 2017;18(5):499-508.
23. Wang S*, Xia P, Fan Z*. Natural-Killer-like B Cells Function as a Separate Subset of Innate B Cells. Immunity. 2017; 47(2):201-202.
24. Xia P, Liu J, Wang S, Ye B, Du Y, Xiong Z, Han ZG, Tong L, Fan Z*. WASH maintains NKp46+ ILC3 cells by promoting AHR expression. Nat Commun. 2017;8:15685.
25. Liu B, Ye B, Zhu X, Huang G, Yang L, Zhu P, Du Y, Wu J, Meng S, Tian Y*, Fan Z*. IL-7Rα glutamylation and activation of transcription factor Sall3 promote group 3 ILC development. Nat Commun. 2017;8(1):231.
26. Ye B, Liu B, Yang L, Huang G, Hao L, Xia P, Wang S, Du Y, Qin X, Zhu P, Wu J, Sakaguchi N, Zhang J, Fan Z*. Suppression of SRCAP chromatin remodelling complex and restriction of lymphoid lineage commitment by Pcid2. Nat Commun. 2017; 8(1): 1518.
27. Yang Z#, Li C#, Fan Z#, Liu H, Zhang X, Cai Z, Xu L, Luo J, Huang Y, He L, Liu C, Wu S. Single-cell Sequencing Reveals Variants in ARID1A, GPRC5A and MLL2 Driving Self-renewal of Human Bladder Cancer Stem Cells. Eur Urol. 2017;71(1):8-12.
28. Yan X, Zhang D, Wu W, Wu S, Qian J, Hao Y, Yan F, Zhu P, Wu J, Huang G, Huang Y, Luo J, Liu X, Liu B, Chen X, Du Y, Chen R*, Fan Z*. Mesenchymal stem cells promote hepatocarcinogenesis via lncRNA-MUF interaction with ANXA2 and miR-34a. Cancer Res. 2017; 77(23):6704-6716.
2016
29. Xia P, Ye B, Wang S, Zhu X, Du Y, Xiong Z, Tian Y*, Fan Z*. Glutamylation of the DNA sensor cGAS regulates its binding and synthase activity in antiviral immunity. Nat Immunol. 2016;17(4):369-78.
30. Wang S, Xia P, Chen Y, Huang G, Xiong Z, Liu J, Li C, Ye B, Du Y, Fan Z*. Natural Killer-like B Cells Prime Innate Lymphocytes against Microbial Infection. Immunity. 2016;45(1):131-44.
31. Zhu P, Wang Y, Huang G, Ye B, Liu B, Wu J, Du Y, He L, Fan Z*. lnc-β-Catm elicits EZH2-dependent β-catenin stabilization and sustains liver CSC self-renewal. Nat Struct Mol Biol. 2016;23(7):631-9.
32. Wang S, Xia P, Huang G, Zhu P, Liu J, Ye B, Du Y, Fan Z*. FoxO1-mediated autophagy is required for NK cell development and innate immunity. Nat Commun. 2016; 7:11023.
33. Zhu P, Wang Y, Wu J, Huang G, Liu B, Ye B, Du Y, Gao G, Tian Y, He L, Fan Z*. LncBRM initiates YAP1 signalling activation to drive self-renewal of liver cancer stem cells. Nat Commun. 2016;7:13608.
34. Li C, Du Y, Yang Z, He L, Wang Y, Hao L, Ding M, Yan R, Wang J*, Fan Z*. GALNT1-Mediated Glycosylation and Activation of Sonic Hedgehog Signaling Maintains the Self-Renewal and Tumor-Initiating Capacity of Bladder Cancer Stem Cells. Cancer Res. 2016;76(5):1273-83.
2015
35. Xia P, Wang S, Ye B, Du Y, Huang G, Zhu P, Fan Z*. Sox2 functions as a sequence-specific DNA sensor in neutrophils to initiate innate immunity against microbial infection. Nat Immunol. 2015; 16(4):366-375.
36. Wang Y, He L, Du Y, Zhu P, Huang G, Luo J, Yan X, Ye B, Li C, Xia P, Zhang G, Tian Y, Chen R*, Fan Z*. The long noncoding RNA lncTCF7 promotes self-renewal of human liver cancer stem cells through activation of Wnt signaling. Cell Stem Cell. 2015; 16(4):413-25.
37. Zhu P, Wang Y, He L, Huang G, Du Y, Zhang G, Yan X, Xia P, Ye B, Wang S, Hao L, Wu J, Fan Z*. ZIC2-dependent OCT4 activation drives self-renewal of human liver cancer stem cells. J Clin Invest. 2015;125(10):3795-808.
38. Xia P, Wang S, Du Y, Huang G, Satoh T, Akira S, Fan Z*. Insulin-InsR signaling drives multipotent progenitor differentiation toward lymphoid lineages. J Exp Med. 2015; 212(13):2305-21.
39. Xia P, Wang S, Xiong Z, Ye B, Huang L, Han Z*, Fan Z*. IRTKS negatively regulates antiviral immunity through PCBP2 sumoylation-mediated MAVS degradation. Nat Commun. 2015;6:8132.
40. Zhu P, Wang Y, Du Y, He L, Huang G, Zhang G, Yan X, Fan Z*. C8orf4 negatively regulates self-renewal of liver cancer stem cells via suppression of NOTCH2 signaling. Nat Commun. 2015; 6:7122.
2014
41. Xia P, Wang S, Huang G, Zhu P, Li M, Ye B, Du Y, Fan Z*. WASH is required for the differentiation commitment of hematopoietic stem cells in a c-Myc-dependent manner. J Exp Med. 2014;211(10): 2119-2134.
42. Ye B, Li C, Yang Z, Wang Y, Hao J, Wang L, Li Y, Du Y, Hao L, Liu B, Wang S, Xia P, Huang G, Sun L, Tian Y*, Fan Z*. Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation. J Exp Med. 2014;211(12):2439-2454.
43. Xia P, Wang S, Huang G, Du Y, Zhu P, Li M, Fan Z*. RNF2 is recruited by WASH to ubiquitinate AMBRA1 leading to downregulation of autophagy. Cell Res., 2014; 24:943–958.
44. Li C, Yang Z, Du Y, Tang H, Chen J, Hu D, Fan Z. BCMab1, A Monoclonal Antibody against Aberrantly Glycosylated Integrin α3β1, Has Potent Antitumor Activity of Bladder Cancer In Vivo. Clin Cancer Res. 2014;20(15):4001-13.
45. Ye B, Dai Z, Liu B, Wang R, Li C, Huang G, Wang S, Xia P, Yang X, Kuwahara K, Sakaguchi N, Fan Z. Pcid2 inactivates developmental genes in human and mouse embryonic stem cells to sustain their pluripotency by modulation of Eid1 stability. Stem Cells. 2014;32(3): 623-635.
2013
46. Wang S, Xia P, Ye B, Huang G, Liu J, Fan Z*. Transient activation of autophagy via Sox2-Mediated suppression of mTOR is an important early step in reprogramming to pluripotency. Cell Stem Cell. 2013;13(5):617–625.
47. Xia P, Wang S, Du Y, Zhao Z, Shi L, Sun L, Huang G, Ye B, Li C, Dai Z, Hou N, Cheng X, Sun Q, Li L, Yang X, Fan Z*. WASH inhibits autophagy through suppression of Beclin 1 ubiquitination. EMBO J. 2013;32(20): 2685-2696.
48. Liu S, Zhang H, Li M, Hu D, Li C, Ge B, Jin B, Fan Z*. Recruitment of Grb2 and SHIP1 by the ITT-like motif of TIGIT suppresses granule polarization and cytotoxicity of NK cells. Cell Death Differ. 2013;20(3):456-464.
2012
49. Wang S, Xia P, Shi L, Fan Z*. FADD cleavage by NK cell granzyme M enhances its self-association to facilitate procaspase-8 recruitment for auto-processing leading to caspase cascade. Cell Death Differ. 2012;19(4):605-615. (IF:8.8)
50. Zhong C, Li C, Wang X, Toyoda T, Gao G, Fan Z*. Granzyme K inhibits replication of influenza virus through cleaving the nuclear transport complex importin α1/β dimer of infected host cells. Cell Death Differ. 2012;19(5):882-890.
2011年以前文章
51. Shi L, Wu L, Wang S, Fan Z*. Granzyme F induces a novel death pathway characterized by Bid-independent cytochrome c release without caspase activation. Cell Death Differ. 2009, 16(12): 1694-1706.
52. Zhao T, Zhang H, Guo Y, Zhang Q, Hua G, Lu H, Hou Q, Liu H, Fan Z*. Granzyme K cleaves the nucleosome assembly protein SET to induce single-stranded DNA nicks of target cells. Cell Death Differ. 2007,14(3): 489-499.
53. Fan Z*, Yu P, Wang Y, Wang Y, Fu ML, Liu W, Sun Y, Fu YX*. NK-cell activation by LIGHT triggers tumor-specific CD8+ T-cell immunity to reject established tumors. Blood. 2006, 107(4): 1342-1351.
54. Fan Z*, Zhang H, Zhang Q. Tumor suppressor pp32 represses cell growth through inhibition of transcription by blocking acetylation and phosphorylation of histone H3 and initiating its proapoptotic activity. Cell Death Differ. 2006, 13(9): 1485-1494.
55. Fan Z, Beresford PJ, Oh DY, Zhang D, Lieberman J*. Tumor suppressor NM23-H1 is a granzyme A-activated DNase during CTL-mediated apoptosis, and the nucleosome assembly protein SET is its inhibitor. Cell 2003, 112(5): 659-672.
56. Fan Z, Beresford PJ, Zhang D, Xu Z, Novina CD, Yoshida A, Pommier Y, Lieberman J*. Cleaving the oxidative repair protein Ape1 enhances cell death mediated by granzyme A. Nat Immunol. 2003, 4(2): 145-153.
57. Lieberman J*, Fan Z*. Nuclear war: the granzyme A-bomb. Curr Opin Immunol. 2003, 15(5): 553-559.
58. Fan Z, Beresford PJ, Zhang D, Lieberman J*. HMG2 interacts with the nucleosome assembly protein SET and is a target of the cytotoxic T-lymphocyte protease granzyme A. Mol Cell Biol. 2002, 22(8): 2810-2820.