王艳东

学术任职：北京化工大学学报编委

研究领域:基因调控与药物开发

科研项目

国家自然科学基金面上项目，81970551，胆汁酸膜受体TGR5（Gpbar1）/miRNA信号轴在肝损伤中的作用机理研究，2020.1-2023.12，主持

➢国家自然科学基金面上项目，81672433，G蛋白偶联受体Gpbar1(TGR5)在胃癌中的作用和分子机制研究， 2017.1-2020.12，主持

➢国家自然科学基金面上项目，胆汁酸受体TGR5在炎症中的作用机制研究，2014.1-2017.12.主持

➢City of Hope GI Cancer Program GI Cancer Research Pilot Project Award, City of Hope National Cancer Center（美国）, 2010-2013, PI, 主持

目的是研究胆酸膜受体TGR5在肝癌中的作用和鉴定其分子机制，评估新药开发的可能性

产生结果: 申请人作为通讯作者发表SCI一区论文2篇（Hepatology. 2011, 54(4), 1421-1432；Hepatology. 2012, [Epub ahead of print]）。

➢Investigation of the roles of nuclear receptor FXR in hepatocellualr carcinoma. (Grant No. R01CA139158), 美国NIH R01基金, 2011-2015, 主要参加人

目的是研究核受体FXR在肝癌治疗中的重要作用

产生结果：本人为该R01基金的成功申请提供了关键性数据和重要论文，并参与了申请书的撰写工作。该基金的申请书是基于本人在2008年作为第一作者报道的两篇重要论文（Hepatology. 2008, 48(5), 1632-1643; Molecular Endocrinology. 2008, 22(7), 1622-1632）。在项目执行期间，本人已经在Hepatology期刊上发表论文2篇（2012），在Journal of Hepatology期刊上发表论文1篇（2011）。

➢Pilot/Feasibility Grant, USC Research Center for Liver Diseases (Grant No. P30DK48522), 2007-2009, 主要参加人

目的是研究核受体FXR在肝脏相关疾病中的作用.

产生结果：申请人发表第一作者SCI论文4篇（Hepatology. 2008, 48(5), 1632-1643; Molecular Endocrinology. 2008, 22(7), 1622-1632. Cell Research. 2008, 18(11), 1087-1095； Histology and Histopathology. 2008, 23(5), 621-627）。

➢The Sidney Kimmel Foundation for Cancer Research, (Grant No. SKF-07-190), 2007-2009, 主要参加人

目的是研究有毒物质诱导和肝癌中的肝脏增生中核受体FXR的作用

产生结果：申请人发表共同第一作者SCI论文2篇（Hepatology. 2010, 51(3), 953-962; Biochim Biophys Acta. 2011, 1812(8), 888-892）。

天津大学优秀博士论文基金，天津大学，2000-2003，主持

目的是利用抑制剂阻断代谢路径法，研究红豆杉细胞中抗癌药物紫杉烷类的生物合成途径以及外界诱导子作用下合成路径的变化；运用数学工具建立植物细胞合成紫杉烷的理论代谢模型。通过模型中代谢通量扰动因子的求解与分析，从碳通量变化的角度揭示紫杉烷类生物合成的运行机制

产生结果：申请人发表第一作者SCI论文4篇（Cell Biology International. 2007, 31(10), 1179-1183; Biochemical Engineering Journal. 2004, 19 (3), 259-265; Plant Cell, Tissue and Organ Culture. 2003, 74, 283-288; Biotechnology and Applied Biochemistry. 2003, 37 (1), 39-43）；第一作者中文论文5篇。

➢The EU grants 'Genetics in a cell line' 和 'Mechanisms of gene integration'，德国，2002-2005，主要参加人

目的是进行DT40 B细胞转录组的研究和鉴定DNA编码酶AID蛋白质复合体成分

产生结果：申请人作为第一作者撰写国际学术专著中的1章（Reviews and Protocols in DT40 Research • Subcellular Biochemistry”， 2006），在SCI期刊上发表论文2篇（Journal of Immunology. 2006, 177(1), 395-400; BMC Genomics. 2004, 5:98）。

代表性学术成果

发表在国际SCI源期刊的学术论文（英文期刊）

1Feng Q, Li Y, Zhang H, Wang Z, Nie X,Yao D, Han L,4 Wei-Dong Chen W.-D., Wang Y.-D.*. Deficiency of miRNA-149-3p shaped gut microbiota and enhanced dextran sulfate sodium-induced colitis. Mol Ther Nucleic Acids. 2022 Dec 13; 30: 208–225.

2. Zhao, Y; Ye, WL; Wang Y.-D.*, Chen, WD. HGF/c-Met: A Key Promoter in Liver Regeneration. Frontiers in Pharmacology, doi: 10.3389/fphar.2022.808855.

2Xiao-Bo Nie, Bao-Sheng Shi, Lin Zhang, Wei-Li Niu, Ting Xue, Lan-Qing Li, Xiao-Yun Wei, Wang Y.-D., Wei-Dong Chen, Rui-Fang Hou. Epidemiological features and dynamic changes in blood biochemical indices for COVID-19 patients in Hebi. World J Clin Cases. 2022 Mar 16; 10(8): 2404–2419.

3Shizhen Zhao, Le Wang, Jie Wang, Chenwei Wang, Shaowei Zheng, Yajie Fu, Yunfu Li, Wei-Dong Chen, Ruifang Hou, Dongbin Yang, Wang Y.-D., Design, synthesis and evaluation of 3-phenoxypyrazine-2-carboxamide derivatives as potent TGR5 agonists. RSC Adv. 2022 Jan 24; 12(6): 3618–3629.

4Xiaobo Nie, Huiyang Liu, Wenling Ye, Xiaoyun Wei, Lili Fan, Han Ma, Lanqing Li, Wanting Xue, Wenting Qi, Wang Y.-D., Wei‐Dong. Chen. LRP5 promotes cancer stem cell traits and chemoresistance in colorectal cancer. J Cell Mol Med. 2022 Feb; 26(4): 1095–1112.

5Xiaobo Nie, Haisheng Wang, Xiaoyun Wei, Lanqing Li, Ting Xue, Lili Fan, Han Ma, Yubing Xia, Wang Y.-D.*, Wei-Dong Chen. LRP5 Promotes Gastric Cancer via Activating Canonical Wnt/beta-Catenin and Glycolysis Pathways. AMERICAN JOURNAL OF PATHOLOGY 2022, 192 (3), 503-517.

6Zixuan Wang, Wei-Dong Chen, Wang Y.-D*. Nuclear receptors: a bridge linking the gut microbiome and the host. Mol Med. 2021; 27: 144.

7Feng Q, Zhang H, Yao D, Zhang X, Chen WD, Wang Y.-D.*, Activation of FXR Suppresses Esophageal Squamous Cell Carcinoma Through Antagonizing ERK1/2 Signaling Pathway. Cancer Management and Research 2021, 13, 5907-5918

8Zhao S, Li X, Wang L, Peng W, Ye W, Li W, Wang Y.-D.*, Chen WD. Design, synthesis and evaluation of 1-benzyl-1H-imidazole-5-carboxamide derivatives as potent TGR5 agonists. Bioorg Med Chem. 2021 Feb 15;32:115972. doi: 10.1016/j.bmc.2020.115972.

9Zhang C，Wang Z, Feng Q, Chen WD, Wang Y.-D*. Farnesoid X receptor: a potential therapeutic target in multiple organs, Histology and Hispathology, 2020 Dec; 35(12):1403-1414. doi: 10.14670/HH-18-301.

10Li M, Chen WD, Wang Y.-D*. The roles of the gut microbiota-miRNA interaction in the host pathophysiology. Mol Med. 2020 Nov 7;26(1):101. doi: 10.1186/s10020-020-00234-7.

11Nie X, Liu H, Liu L, Wang Y.-D*., Chen WD. Emerging Roles of Wnt Ligands in Human Colorectal Cancer. Front Oncol. 2020 Aug 14;10:1341. doi: 10.3389/fonc.2020.01341. eCollection 2020.

12Wang J, Chen WD, Wang Y.-D*. The Relationship Between Gut Microbiota and Inflammatory Diseases: The Role of Macrophages. Front Microbiol. 2020 Jun 9;11:1065. doi: 10.3389/fmicb.2020.01065. eCollection 2020.

13Lv SY, Chen WD, Wang Y.-D*. The Apelin/APJ System in Psychosis and Neuropathy. Front Pharmacol. 2020 Mar 13;11:320. doi: 10.3389/fphar.2020.00320. eCollection 2020.

14Feng Q, Zhang H, Nie X, Li Y, Chen WD, Wang Y.-D*. miR-149* Suppresses Liver Cancer Progression by Down-Regulating Tumor Necrosis Factor Receptor 1-Associated Death Domain Protein Expression. Am J Pathol. 2020 Feb;190(2):469-483. doi: 10.1016/j.ajpath.2019.10.010. Epub 2019 Nov 26.

15Feng Q, Zhang H, Yao D, Chen WD, Wang Y.-D*. Emerging Role of Non-Coding RNAs in Esophageal Squamous Cell Carcinoma. Int J Mol Sci. 2019 Dec 30;21(1):258. doi: 10.3390/ijms21010258.

16Nie X, Xia F, Liu Y, Zhou Y, Ye W, Hean P, Meng J, Liu H, Liu L, Wen J, Ren X, Chen WD, Wang Y.-D*. Downregulation of Wnt3 Suppresses Colorectal Cancer Development Through Inhibiting Cell Proliferation and Migration. Front Pharmacol. 2019 Oct 1;10:1110. doi: 10.3389/fphar.2019.01110. eCollection 2019.

17Lv SY, Zhou YC, Zhang XM, Chen WD, Wang Y.-D*. Emerging Roles of NPQ/Spexin in Physiology and Pathology. Front Pharmacol. 2019 May 7;10:457. doi: 10.3389/fphar.2019.00457. eCollection 2019. Review.

18Lv, S.-Y., Cui, B., Yang, Y., Du, H., Zhang, X., Zhou, Y., Ye, W., Nie, X., Li, Y., Wang, Q., Chen, W.-D., Wang, Y.-D*. Spexin/NPQ Induces Fos and Produces Antinociceptive Effect against Inflammatory Pain in the Mouse Model. Am J Pathol. 2019 Jan 19. pii: S0002-9440(18)30290-6. doi: 10.1016/j.ajpath.2018.12.009. [Epub ahead of print]

19Zhang, H., Feng, Q., Chen, W.-D., Wang, Y.-D*. HGF/c-MET: A Promising Therapeutic Target in the Digestive System Cancers. Int J Mol Sci. 2018 Oct 23;19(11). pii: E3295. doi: 10.3390/ijms19113295. Review.

20Nie, X., Liu, Y., Chen, W.-D., Wang, Y.-D*. Interplay of miRNAs and Canonical Wnt Signaling Pathway in Hepatocellular Carcinoma. Front Pharmacol. 2018 Jun 21;9:657. doi: 10.3389/fphar.2018.00657. eCollection 2018.

21Feng, Q., Chen, W.-D., Wang, Y.-D*. Gut Microbiota: An Integral Moderator in Health and Disease. Front Microbiol. 2018 Feb 21;9:151. doi: 10.3389/fmicb.2018.00151. eCollection 2018. (2018-2021年度高被引论文)

22Lv, X., Kong, J., Chen, W.-D., Wang, Y.-D.* The Role of the Apelin/APJ System in the Regulation of Liver Disease. Front Pharmacol. 2017;8:221. doi: 10.3389/fphar.2017.00221.

23Sun, X.，Chen, W.-D.，Wang, Y.-D..* DAF-16/FOXO Transcription Factor in Aging and Longevity，Front. Pharmacol. 2017;8:548. doi: 10.3389/fphar.2017.00548.

24Zhang, Q.，Su, J.，Wang, Z.，Qi, H.，Ge, .，Li, Z.，Chen, W.-D.，Wang, Y.-D..* MicroRNA-149*suppresses hepatic inflammatory response through antagonizing STAT3 signaling pathway，Oncotarget，2017，8(39)：65397~65406

25Lv, S.，Cui, B.，Chen, W.-D.，Wang, Y.-D..* Apelin/APJ system -A key therapeutic target for liver disease，Oncotarget，2017;8(67):112145-112151. doi: 10.18632/oncotarget.22841.

26Su, J., Zhang, Q., Qi, H., Wu, L., Li, Y., Yu, D., Huang, W., Chen, W.-D., Wang, Y.-D..* The G-protein-coupled bile acid receptor Gpbar1 (TGR5) protects against renal inflammation and renal cancer cell proliferation and migration through antagonizing NF-κB and STAT3 signaling pathways. Oncotarget, 2017, 8(33)：54378~54387

27Xue, F., Nie, X., Shi, J., Liu, Q., Wang, Z., Li, X., Zhou, J., Su, J., Xue, M., Chen, W.-D., Wang, Y.-D.* Quercetin Inhibits LPS-Induced Inflammation and ox-LDL-Induced Lipid Deposition. Front Pharmacol. 2017 Feb 3;8:40. doi: 10.3389/fphar.2017.00040.

28Guo, C., Chen, W.-D., Wang, Y.-D.* TGR5, Not Only a Metabolic Regulator. Front Physiol. 2016 Dec 26;7:646. doi: 10.3389/fphys.2016.00646.

29Wang, H., Nie, X., Wu, R., Yuan, H., Ma, Y., Liu, X., Zhang, J., Deng, X., Na, Q., Jin, H., Bian, Y., Gao, Y., Wang, Y.-D.,* Chen, W.-D.. * Down-regulation of human Wnt3 in gastric cancer suppresses cell proliferation and induces apoptosis, OncoTargets and Therapy. 2016 Jun 27;9:3849-60. doi: 10.2147/OTT.S101782.

30Guo, C., Su, J., Li, Z., Xiao, R., Wen, J., Li, Y., Zhang, M., Zhang, X., Yu, D., Huang, W., Chen, W.-D., Wang, Y.-D..* The G-protein-coupled bile acid receptor Gpbar1 (TGR5) suppresses gastric cancer cell proliferation and migration through antagonizing STAT3 signaling pathway. Oncotarget. 2015,27; 6(33):34402-34413.

31Guo, C., Qi, H., Yu, Y., Zhang, Q., Su, J., Yu, D., Huang, W., Chen, W.-D., Wang, Y.-D..* The G-protein-coupled bile acid receptor Gpbar1 (TGR5) inhibits gastric inflammation through antagonizing NF-kB signaling pathway. Front. Pharmacol. 2015,6:287., doi: 10.3389/fphar.2015.00287

32Sun, X., Chen, W.-D., Wang, Y.-D..* β-Amyloid:the key peptide in the pathogenesis of Alzheimer’sdisease.Front. Pharmacol. 2015，6:221., doi:10.3389/fphar.2015.00221

33Wang, Y.-D,* W.-D. Chen, C. Li, , C. Guo, , Y. Li, , H. Qi,, H. Shen, J. Kong, , X. Long, , F.  Yuan, , X. Wang, , W. Huang. Farnesoid X Receptor Antagonizes JNK Signaling Pathway in Liver Carcinogenesis by Activating SOD3. Mol Endocrinol. 2015,29(2):322-331.

34Lou, G., Ma, X., Fu, X., Meng, Z., Zhang, W., Wang, Y.-D., Van, Ness C., Yu, D., Xu, R., Huang, W. Gpbar1/TGR5 mediates bile acid-induced cytokine expression in murine Kupffer cells. PloS One. 2014, 9(4):e93567.

35Wang, Y.-D.*, Chen, W.-D., Yu, D., Forman, B.M and Huang, W. The G-protein-coupled bile acid receptor, Gpbar1 (TGR5), negatively regulates hepatic inflammatory response through antagonizing nuclear factor κ light-chain enhancer of activated B cells (NF-κB) in mice. Hepatology. 2011, 54(4), 1421-1432.

2021年度高被引论文。

36Chen, W.-D.*, Wang, Y.-D.*, Zhang, L., Shiah, S., Wang, M., Yang, F., Yu, D., Forman, B.M and Huang, W. Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers by activating forkhead box m1b transcription. Hepatology. 2010, 51(3), 953-962.

 *同等贡献第一作者

37Chen, W.-D.*, Wang, Y.-D.*, Meng, Z., Zhang, L. and Huang, W. Nuclear bile acid receptor FXR in the hepatic regeneration. Biochimica et Biophysica Acta-Molecular Basis of Disease. 2011, 1812(8), 888-892. （SCI二区，影响因子为5.387）

*同等贡献第一作者

38Wang, Y.-D., Chen, W.-D., Wang, M., Yu, D., Forman, B.M. and Huang, W.  Farnesoid X receptor antagonizes NF-κB in hepatic inflammatory response. Hepatology. 2008, 48(5), 1632-1643.（

•Faculty of 1000 Biology推荐必读论文

39Wang, Y.-D., Chen, W.-D. and Huang, W. FXR: a metabolic regulator and a cell protector. Cell Research. 2008, 18(11), 1087-1095.（SCI一区，影响因子为8.19）

•Faculty of 1000 Medicine推荐必读论文

40Wang, Y.-D., Yang, F., Chen, W.-D., Huang, X., Lai, L., Forman, B.M. and Huang, W. Farnesoid x receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo. Molecular Endocrinology. 2008, 22(7), 1622-1632.（SCI二区，影响因子为4.54）

•该研究工作被Endocrine News（2008, July, 13）专题报道

41Wang, Y.-D., Chen, W.-D. and Huang, W. FXR, a target for different diseases. Histology and Histopathology. 2008, 23(5), 621-627.

42Wang, Y.-D., Wu, J. and Yuan, Y.-J. Salicylic acid-induced taxol production and isopentenyl pyrophosphate biosynthesis in suspension cultures of Taxus chinensis var. mairei. Cell Biology International. 2007, 31(10), 1179-1183.

43Wang, Y.-D., Yan, Y.-J. and Wu, J. Induction studies of methyl jasmonate and salicylic acid on taxane production in suspension cultures of Taxus chinensis var. mairei. Biochemical Engineering Journal. 2004, 19 (3), 259-265.

44Wang, Y.-D., Yan, Y.-J. and Wu, J. Translocation of isopentenyl pyrophosphate for Taxol biosynthesis in suspension cultures of Taxus chinensis var. mairei. Plant Cell, Tissue and Organ Culture. 2003, 74, 283-288.

45Wang, Y.-D., Yan, Y.-J., Lu, M, Wu, J. and Jiang, J.-L. Inhibitor studies of isopentenyl pyrophosphate biosynthesis in suspension cultures of the yew Taxus chinensis var. mairei. Biotechnology and Applied Biochemistry. 2003, 37 (1), 39-43.（

46Zhang, L., Wang, Y.-D., Chen, W.-D., Wang, X., Lou, G., Liu, N., Lin, M., Forman, B.M. and Huang, W. Promotion of liver regeneration/repair by farnesoid X receptor in both liver and intestine. Hepatology. 2012,56（6），2336-2343 （

47Meng, Z., Wang, Y.-D., Wang, L., Jin, W., Liu, N., Pan, H., Liu, L., Wagman, L., Forman, B.M and Huang, W. FXR regulates liver repair after CCl4-induced toxic injury. Molecular Endocrinology. 2010, 24(5), 886-897.

48Chen, W.-D., Wang, Y.-D., Hu, H.-H. and Su, Z.-G. Hydrodynamics in an expanded bed of large size ion-exchange resin, and natural product adsorption. Journal of Chemical Technology and Biotechnology. 2007, 82, 135–142.

49Chen, W.-D., Wang, Y.-D. and Su, Z.-G. Suitability of steric mass-action model for ion-exchange equilibrium of micromolecule. Chinese Journal of Chemical Engineering. 2005, 13 (1), 17-22.

50Chen, W.-D., Wang, Y.-D., Zha L.-H., Ma, G.-H. and Su, Z.-G. Single-step recovery of ephedrine hydrochloride from raw materials using expanded bed adsorption. Biotechnology Letters. 2004, 26,1233-1236.（

51Schoetz, U., Cervelli, M., Wang, Y.-D., Fiedler, P. and Buerstedde, J.-M. E2A expression stimulates Ig hypermutation. Journal of Immunology. 2006, 177(1), 395-400.

52Chen, W.-D., Hu, H.-H. and Wang, Y.-D. Analysis of steric mass-action model for protein adsorption equilibrium onto porous anion-exchange adsorbent. Chemical Engineering Science. 2006, 61, 7068-7076.

53Ge, Z., Yuan, Y.-J., Wang, Y.-D., Ma, Z. and Hu. Z. Ce4+-induced apoptosis of Taxus cuspidata cells in suspension cultures. Journal of Rare Earths. 2002, 20,139-144.

54Chen, W.-D., Fu, X., Dong, B., Wang, Y.-D., Shiah, S., Moore, D.D and Huang, W. Neonatal activation of the nuclear receptor CAR results in epigenetic memory and permanent change of drug metabolism in mouse liver. Hepatology. 2012,56（4），1499-1509.

55Meng, Z., Liu, N., Fu, X., Wang, X., Wang, Y.-D., Chen, W.-D., Zhang, L., Forman, B.M and Huang, W. Insufficient bile acid signaling impairs liver repair in CYP27-/- mice. Journal of Hepatology. 2011, 55(4), 885-895.

56Wahl, M.B., Caldwell, R.B., Kierzek, A.M., Arakawa1, H., Eyras, E., Hubner, N., Jung, C., Soeldenwagner, M., Cervelli1, M., Wang, Y.-D., Liebscher, V. and Buerstedde. J.-M. Evaluation of the chicken transcriptome by SAGE of B cells and the DT40 cell line. BMC Genomics. 2004, 5:98 (http://www. Biomedcentral.com/1471-2164/5/98) 

发表在中文期刊的学术论文

1王艳东, 元英进, 路明, 吴金川. Methyl jasmonate-induced cytochrome P-450 monooxygenase in suspension cultures of Taxus chinensis var. mairei. 化工学报, 2002, 53 (增刊), 175-177.

2王艳东, 路明, 元英进. 甲基茉莉酮酸对悬浮培养南方红豆杉细胞代谢的影响. 中草药, 2003, 34 (1), 27-30.

3王艳东, 马振毅, 元英进. 外源紫杉醇作用下南方红豆杉细胞凋亡及动力学研究. 化学工程, 2002, 30 (5), 53-57.

4王艳东, 葛志强, 马振毅, 元英进. 外加紫杉醇后南方红豆杉细胞的耐受性极其凋亡的研究. 高校化学工程学报, 2002, 16 (4), 421-425.

5王艳东, 路明, 元英进. 甲基茉莉酮酸对悬浮培养南方红豆杉细胞生理态势的影响. 精细与专用化学品, 2002(增刊), 616-620.

6路明, 王艳东, 许明丽, 元英进. 甲基茉莉酮酸对悬浮培养南方红豆杉细胞自由基清除系统酶的影响. 中草药, 2002, 33 (11), 985-988.

7马振毅, 王艳东, 元英进. 外加紫杉醇对悬浮培养东北红豆杉细胞的诱导效应. 生物工程学报, 2002, 18 (2), 204-207.

8元英进, 葛志强, 王艳东, 马振毅, 胡宗定. 铈诱导悬浮培养的东北红豆杉细胞发生凋亡. 中国稀土学报, 2001, 19 (4), 357-361.

9胡国武, 马征, 王艳东, 元英进. 稀土对红豆杉细胞中紫杉烯合成酶基因转录的影响. 中国稀土学报, 2000, 18 (4), 360-362.

➢发表在国际期刊的学术评论回复短文

1Wang, Y.-D., Chen, W.-D. and Huang, W. Gastroenterology. 2009, 137(2), 736.（SCI一区，影响因子为11.68）

➢参编国际学术著作

1Wang, Y.-D., Chen, W.-D. The Role of Bile Acids in Different Diseases in Book “Bile Acids: Biosynthesis, Metabolic Regulation and Biological Functions”, Nova Science Publishers, Inc.,2016.

2Wang, Y.-D., Chen, W.-D., Chen, X.-S. and Huang, W. “FXR” in the book of “Nuclear Receptors • Current Concepts and Future Challenges” Series: Proteins and Cell Regulation (Editors: Bunce, Chris; Campbell, Moray J), Vol. 8, Springer, Netherlands, March. 2010, 307-326.

3Wang, Y.-D. and Caldwell R.B. “Isolation of nuclear and cytoplasmic proteins from DT40 cells” in the book of “Reviews and Protocols in DT40 Research • Subcellular Biochemistry” (Editors: Buerstedde, J.-M. and Takeda, S.), Vol. 40, Springer, New York, 2006, 439-440.

➢参编国内学术著作

1王艳东, 葛志强, 元英进. 第八章“紫杉醇和多烯紫杉醇的临床前研究”, in: 抗癌药物紫杉醇和多烯紫杉醇 （主编，元英进）化学工业出版社, 2002年11月.

2王艳东, 葛志强, 元英进. 第九章“紫杉醇和多烯紫杉醇临床研究”, in: 抗癌药物紫杉醇和多烯紫杉醇 （主编，元英进）化学工业出版社, 2002年11月.

3李景川, 王艳东, 元英进. 第六章“紫杉醇的生物合成”, in: 抗癌药物紫杉醇和多烯紫杉醇（主编，元英进）化学工业出版社, 2002年11月.

4元英进, 王艳东. 第一章“概述”, in: 植物细胞培养工程（主编，元英进）化学工业出版社, 2004年.

➢专利

1. LRP5作为临床诊断和抑制消化系统肿瘤的的应用。王艳东，陈卫东，聂小博，王海生，高玉敏，  徐晓，周云。中国发明专利，专利号 ZL201710124101.3

2. NGF作为用于治疗食管癌的药物及诊断试剂盒的应用。王艳东，李慧。中国发明专利，申请号202110532519.4

3. 一种小鼠运动模型的建立方法。王艳东，李子柔。中国发明专利，申请号 202110524730.1

4.  LPCAT1基因在制备治疗癌症药物及诊断试剂盒中的应用。王艳东，王泓月。中国发明专利，申请号 202110524719.5

5. LPCAT1基因在制备治疗肝脏炎症药物及诊断试剂盒中的应用。王艳东，咬登麟。中国发明专利，申请号 202110524716.5

6. STAMBPL1作为用于治疗食管癌的药物及诊断试剂盒的应用。王艳东，刘嘉轩。中国发明专利，申请号 202110802105.X

7. 长链非编码RNALinc01605在作为胃癌诊断性试剂盒及靶向药物开发中的应用。王艳东，邓力郝。中国发明专利，申请号 202110841671.0

学术交流

国际会议发言及展示

1.TGR5 signaling protects against inflammatory bowel diseases through antagonizing NF-κB signaling and reactive oxygen species generation. Digestive Disease Week, 2012, San Diego, California, USA

2.Farnesoid X receptor alleviates age-related proliferation defects in regenerating mouse livers. Keystone meeting; Nuclear Receptors: Development, Physiology and Disease, 2010, Colorado, USA

3.FXR suppresses JNK signaling preventing liver from tumorignensis. The Meeting of LA area Receptor labs, April 24, 2009, Duarte, California, USA

4.Novel roles of FXR in hepatic inflammation and hepatocarcinogenesis. Keystone meeting; orphan receptor, 2008, Whistler, British Columbia, Canada

5.FXR regulates liver repair after CCl4-induced injury. Nuclear receptors: bench to bedside, 2008, Cold Spring Harbor Laboratory, New York, USA

6.Bile acids induce the expression of the Foxm1b gene via activation of the Farnesoid X receptor contributing to aged mice liver regeneration. 28th Annual Advance of the Research Staff Organization of City of Hope, 2008, Lake Arrowhead, California, USA

7.FXR plays a protective role in HepG2 cell apoptosis induced by serum deprivation. The Meeting of LA area Receptor labs, April 20, 2007, Duarte, California, USA

8.Differentiation in Taxus chinensis var. mairei cell suspension cultures. APBIO'99 meeting, 1999, Hong Kong, China

➢国内会议论文

1.王艳东, 路明, 元英进. 甲基茉莉酮酸对悬浮培养南方红豆杉细胞生理态势的影响. 第十届全国生物化工学术会议论文集. 2002, 杭州, 中国, 616-620.

2.路明, 王艳东, 元英进. 悬浮培养南方红豆杉细胞紫杉醇生物合成的代谢调控. 第一界全国中药现代化研讨会论文集. 2002, 天津, 中国, 295-299.

3.马振毅, 王艳东, 元英进. 东北红豆杉细胞悬浮培养过程中内切壳聚糖酶基因的诱导表达. 第九届全国生物化工学术会议论文集. 2000, 天津, 中国, 572-575.